Poster Presentation 9th Australasian Virology Society Meeting 2017

Localised outbreaks of epidemic polyarthritis among Australian Defence Force personnel in Shoalwater Bay Training Area (Central Queensland) in 2016 and 2017 due to different lineages of Ross River virus (#160)

jo Kizu 1 , Christopher Moller 1 , john aaskov 1 2 , Ania Gubala 3 , Wenjun Liu 1
  1. Australia Army Malaria Research Institute, Enoggera, QLD, Australia
  2. Institute of Health and Biomedical Innovation, Queensland University of Technology, Brisbane, Queensland, Australia
  3. Land Division, Defence Science and Technology Group, Fishermans Bend, VIC 32074. , Australia

Arboviral infections are a significant threat to the health of Australian Defence Force (ADF) personnel with the potential to reduce operational capability. In March 2016, 28 of 128 personnel from a single unit had laboratory confirmed Ross River virus (RRV) infections following a military training exercise in the Shoalwater Bay Training Area (SWBTA) in central Queensland. In May 2017, 34 ADF personnel presented with symptoms of epidemic polyarthritis while on a military training exercise in same area. In both outbreaks, the location of the patients and the timing of the onset of symptoms suggested person-mosquito-person transmission of virus. As part of the outbreak investigation, consent was obtained to attempt viral isolation from 7 serum samples from the 2016 outbreak and 10 serum samples from the 2017 outbreak. RRV was isolated from one 2017 sample and one 2016 sample.  Phylogenetic analysis of envelope gene 2 (E2) and non-structural protein 3 (nsP3) genes revealed that these two viruses belonged to two different lineages. The 2016 ADF isolate most closely resembled a strain of RRV recovered in Queensland in 2004 (QML1) (99.3% nucleotide and amino acid identity) while the 2017 ADF isolate most closely resembled strains of RRV isolated in Queensland more recently (2015) (99.8% nucleotide and 99.3% amino acid identity). Direct comparison of the  E2 protein of both RRVs revealed there is one N-glycosylation site and 6 amino acid changes located at A and C domains of E2, which are important for interaction with the E1 protein. The nsP3 genes of both the RRVs contained the repeated 12 amino acid sequence element characteristic of post-1979 strains of RRVs. These results indicate that two different RRVs caused the 2016 and 2017 ADF SWBTA outbreaks. The re-emergence of the QML1 lineage may pose a problem for the ADF and for public health in Australia.